Research Articles
miRNA vs. lncRNA in HCC Diagnosis: A Comprehensive Comparison of Accuracy and Clinical Utility
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, often diagnosed at advanced stages due to a lack of sensitive early detection tools.
Conformational Selection vs. Induced Fit: Decoding Molecular Recognition Mechanisms for Advanced Drug Design
This article provides a comprehensive analysis of the two dominant paradigms in molecular recognition—conformational selection and induced fit—and their critical implications for structure-based drug discovery.
Protein-Small Molecule Binding Thermodynamics: From Molecular Basis to Drug Discovery Applications
This comprehensive review explores the molecular basis of protein-small molecule binding thermodynamics, addressing the critical needs of researchers and drug development professionals.
Head-to-Head Comparison of ncRNA Panels for Early HCC Detection: A Roadmap for Researchers and Developers
Hepatocellular carcinoma (HCC) is a global health threat with a poor prognosis, largely due to late diagnosis.
LINC00152 as an Independent Prognostic Biomarker in Hepatocellular Carcinoma: From Mechanistic Insights to Clinical Application
This comprehensive review synthesizes current evidence on the long non-coding RNA LINC00152 as a potent independent prognostic biomarker in hepatocellular carcinoma (HCC).
Circular RNAs vs. Long Non-Coding RNAs: A Comparative Analysis of Stability in HCC Liquid Biopsy
Liquid biopsy has emerged as a transformative, non-invasive approach for the management of hepatocellular carcinoma (HCC).
Validating lncRNA Prognostic Signatures in Hepatocellular Carcinoma: From Bench to Bedside
Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide, with a 5-year survival rate below 20% for advanced-stage patients.
Independent Prognostic lncRNA Biomarkers in HCC: From Multivariate Cox Validation to Clinical Translation
This article synthesizes current advancements in validating long non-coding RNA (lncRNA) biomarkers for hepatocellular carcinoma (HCC) prognosis using multivariate Cox regression models.
Single vs. Combined lncRNA Biomarkers in HCC: A Comprehensive Review of Diagnostic and Prognostic Efficacy
Hepatocellular carcinoma (HCC) is a global health challenge with high mortality, largely due to late diagnosis.
Tissue vs. Circulating lncRNAs: A Comparative Analysis for Advancing Hepatocellular Carcinoma Diagnosis
Hepatocellular carcinoma (HCC) presents a significant global health burden, with poor prognosis often due to late diagnosis.