Research Articles
HBV-Induced Non-Coding RNA Alterations in Hepatocarcinogenesis: Mechanisms, Biomarkers, and Therapeutic Avenues
Hepatitis B virus (HBV) is a primary etiology of hepatocellular carcinoma (HCC), accounting for over half of all cases globally.
Decoding the lncRNA-mRNA Regulatory Network in Liver Cancer: From Mechanisms to Clinical Applications
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression in hepatocellular carcinoma (HCC), interacting with mRNAs through complex networks to drive tumor initiation, progression, and therapy resistance.
Non-Coding RNA Dysregulation in the Hepatocellular Carcinoma Tumor Microenvironment: Mechanisms, Biomarkers, and Therapeutic Avenues
This article comprehensively explores the critical roles of non-coding RNAs (ncRNAs)—including miRNAs, lncRNAs, and circRNAs—in reshaping the hepatocellular carcinoma (HCC) tumor microenvironment (TME).
LncRNAs in Hepatocellular Carcinoma: From Molecular Mechanisms to Clinical Applications in Diagnosis and Therapy
This article comprehensively reviews the critical role of long non-coding RNAs (lncRNAs) in the pathogenesis of hepatocellular carcinoma (HCC), the most common form of primary liver cancer.
SOX9 as an Emerging Immune Biomarker: Performance, Mechanisms, and Clinical Potential Versus Established Markers
This review synthesizes current evidence on the transcription factor SOX9 as a novel immunomodulatory biomarker in cancer.
SOX9 in Oncology: A Dual-Faced Regulator Across Solid and Hematological Malignancies
This article synthesizes current research on the transcription factor SOX9, exploring its complex and context-dependent roles in cancer biology.
SOX Family Cross-Talk in Immune Regulation: Unraveling SOX9 Networks for Cancer Immunotherapy
This review synthesizes current research on the complex interplay between SOX9 and other SOX family transcription factors in regulating immune responses, particularly in cancer.
SOX9 in Cancer Immunology: A Dual-Role Regulator of Tumor Immunity and Therapeutic Target
This comprehensive review explores the complex, context-dependent role of the transcription factor SOX9 in modulating immune responses within tumor microenvironments compared to normal tissues.
SOX9 in Immunity: Conserved Targets and Divergent Functions Across Species
The transcription factor SOX9 is a pivotal, yet dualistic, regulator of the immune system, playing context-dependent roles in cancer immune escape, inflammatory diseases, and tissue repair.
SOX9 and Immune Checkpoints: A Dual-Edged Sword in Cancer Immunobiology and Therapeutic Targeting
This article synthesizes current research on the transcription factor SOX9 and its complex correlation with immune checkpoint markers across various cancers.