Research Articles
Circulating lncRNAs as Liquid Biopsy Biomarkers in Liver Cancer: From Mechanism to Clinical Translation
Liquid biopsy analysis of circulating long non-coding RNAs (lncRNAs) represents a transformative approach for the non-invasive management of hepatocellular carcinoma (HCC).
Decoding HCC Heterogeneity: Single-Cell RNA Sequencing Reveals ncRNA Drivers of Tumor Progression and Therapy Resistance
This comprehensive review explores the critical role of single-cell RNA sequencing (scRNA-seq) in unraveling non-coding RNA (ncRNA) heterogeneity in Hepatocellular Carcinoma (HCC).
LncRNAs as Clinical Tools: From Discovery to Diagnostic Validation in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis.
A Comprehensive Guide to lncRNA In Situ Hybridization in Hepatocellular Carcinoma: From Basic Protocol to Clinical Validation
This article provides a comprehensive methodological framework for researchers and drug development professionals aiming to precisely localize long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) tissues using in situ hybridization...
Leveraging lncRNA Expression Panels for Early Hepatocellular Carcinoma Detection: From Biomarker Discovery to Clinical Application
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis.
LncRNA Classification and Molecular Functions in Hepatocellular Carcinoma: From Mechanisms to Precision Therapeutics
Hepatocellular carcinoma (HCC) remains a global health challenge with high mortality, driving urgent need for novel diagnostic biomarkers and therapeutic strategies.
Revolutionizing HCC Diagnosis: Machine Learning Integration of lncRNA Biomarkers
Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality globally, largely due to limitations in early detection.
A Comprehensive qRT-PCR Protocol for lncRNA Detection in Hepatocellular Carcinoma Plasma Samples
This article provides a detailed methodological guide for detecting long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) plasma samples using quantitative reverse transcription PCR (qRT-PCR).
Non-Coding RNAs as Master Regulators of the PI3K/AKT Pathway in Hepatocellular Carcinoma: Mechanisms, Therapeutic Targeting, and Clinical Perspectives
Hepatocellular carcinoma (HCC) is a global health challenge with limited therapeutic options and a poor prognosis.
Unraveling the Epigenetic Code: Mechanisms of lncRNA HOTAIR in Hepatocellular Carcinoma Pathogenesis and Therapy
This article comprehensively explores the multifaceted epigenetic mechanisms by which the long non-coding RNA HOTAIR drives hepatocellular carcinoma (HCC) progression.