Research Articles
A Comprehensive qRT-PCR Protocol for lncRNA Detection in Hepatocellular Carcinoma Plasma Samples
This article provides a detailed methodological guide for detecting long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) plasma samples using quantitative reverse transcription PCR (qRT-PCR).
Non-Coding RNAs as Master Regulators of the PI3K/AKT Pathway in Hepatocellular Carcinoma: Mechanisms, Therapeutic Targeting, and Clinical Perspectives
Hepatocellular carcinoma (HCC) is a global health challenge with limited therapeutic options and a poor prognosis.
Unraveling the Epigenetic Code: Mechanisms of lncRNA HOTAIR in Hepatocellular Carcinoma Pathogenesis and Therapy
This article comprehensively explores the multifaceted epigenetic mechanisms by which the long non-coding RNA HOTAIR drives hepatocellular carcinoma (HCC) progression.
HBV-Induced Non-Coding RNA Alterations in Hepatocarcinogenesis: Mechanisms, Biomarkers, and Therapeutic Avenues
Hepatitis B virus (HBV) is a primary etiology of hepatocellular carcinoma (HCC), accounting for over half of all cases globally.
Decoding the lncRNA-mRNA Regulatory Network in Liver Cancer: From Mechanisms to Clinical Applications
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression in hepatocellular carcinoma (HCC), interacting with mRNAs through complex networks to drive tumor initiation, progression, and therapy resistance.
Non-Coding RNA Dysregulation in the Hepatocellular Carcinoma Tumor Microenvironment: Mechanisms, Biomarkers, and Therapeutic Avenues
This article comprehensively explores the critical roles of non-coding RNAs (ncRNAs)—including miRNAs, lncRNAs, and circRNAs—in reshaping the hepatocellular carcinoma (HCC) tumor microenvironment (TME).
LncRNAs in Hepatocellular Carcinoma: From Molecular Mechanisms to Clinical Applications in Diagnosis and Therapy
This article comprehensively reviews the critical role of long non-coding RNAs (lncRNAs) in the pathogenesis of hepatocellular carcinoma (HCC), the most common form of primary liver cancer.
SOX9 as an Emerging Immune Biomarker: Performance, Mechanisms, and Clinical Potential Versus Established Markers
This review synthesizes current evidence on the transcription factor SOX9 as a novel immunomodulatory biomarker in cancer.
SOX9 in Oncology: A Dual-Faced Regulator Across Solid and Hematological Malignancies
This article synthesizes current research on the transcription factor SOX9, exploring its complex and context-dependent roles in cancer biology.
SOX Family Cross-Talk in Immune Regulation: Unraveling SOX9 Networks for Cancer Immunotherapy
This review synthesizes current research on the complex interplay between SOX9 and other SOX family transcription factors in regulating immune responses, particularly in cancer.