Research Articles
Optimizing Molecular Descriptor Selection with RFE and 1D-CNN: A Guide for Enhanced QSAR and Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on integrating Recursive Feature Elimination (RFE) with 1D Convolutional Neural Networks (1D-CNN) to optimize molecular descriptor selection.
PICADAR vs. Nasal Nitric Oxide: A Comparative Analysis of PCD Diagnostic Tools for Research and Clinical Development
This article provides a critical analysis of two primary screening tools for Primary Ciliary Dyskinesia (PCD): the PICADAR clinical prediction rule and nasal Nitric Oxide (nNO) measurement.
Systematic Evaluation of PICADAR: Diagnostic Accuracy, Limitations, and Future Directions in Large PCD Cohorts
This article provides a comprehensive evaluation of the Primary Ciliary Dyskinesia Rule (PICADAR) predictive tool based on recent large-scale cohort studies.
Enhancing PCD Diagnosis: Integrating Nasal Nitric Oxide with the PICADAR Score for Improved Screening
This article examines the synergistic combination of the PICADAR clinical prediction rule and nasal nitric oxide (nNO) measurement for screening Primary Ciliary Dyskinesia (PCD).
Beyond the Score: Critical Limitations of the PICADAR Tool in Modern PCD Diagnosis and Clinical Practice
The Primary Ciliary Dyskinesia Rule (PICADAR) is a clinical prediction tool recommended by the European Respiratory Society to estimate the likelihood of a PCD diagnosis.
PICADAR Score Limitations: Assessing Diagnostic Sensitivity in PCD Patients with Situs Solitus
This article critically evaluates the PICADAR score, a clinical prediction tool for Primary Ciliary Dyskinesia (PCD), with a specific focus on its significantly reduced sensitivity in patients with situs solitus...
Beyond the Score: Critical Limitations of PICADAR in Modern Primary Ciliary Dyskinesia Diagnosis
This article provides a critical analysis of the PICADAR (PrImary CiliARy DyskinesiA Rule) score, a predictive tool for Primary Ciliary Dyskinesia (PCD).
Harnessing dCas9 Systems: A Comprehensive Guide to Reversible Gene Expression Control for Research and Therapy
This article provides a comprehensive exploration of dead Cas9 (dCas9) systems, which have revolutionized genetic research by enabling precise, reversible control over gene expression without creating DNA double-strand breaks.
RNP Complex Delivery: A Strategic Approach to Minimize CRISPR Off-Target Effects
The therapeutic application of CRISPR-Cas9 genome editing is significantly hampered by off-target effects, which pose safety risks in clinical settings.
CRISPR-Cas9 Beta-Globin Mutation Correction: From Molecular Basis to Clinical Therapy in Sickle Cell Disease
This comprehensive review synthesizes current advancements in CRISPR-based gene editing strategies for correcting the beta-globin mutation in sickle cell disease (SCD).