Research Articles
Targeting SOX9 in Tumor-Associated Macrophages: A Comprehensive Protocol for Knockdown and Functional Analysis in the Tumor Microenvironment
This article provides a detailed methodological and conceptual framework for researchers aiming to investigate the role of SOX9 in tumor-associated macrophages (TAMs).
Targeting SOX9 to Overcome Resistance to PD-1/PD-L1 Blockade in Cancer
Combining SOX9 inhibition with PD-1/PD-L1 blockade represents a promising strategy to overcome immunotherapy resistance in solid tumors.
Targeting SOX9 in Cancer Immunotherapy: Mechanisms, Inhibition Strategies, and Clinical Outlook
The transcription factor SOX9 emerges as a pivotal, yet dualistic, regulator in cancer biology and tumor immunology.
SOX9 at the Crossroads: Decoding Its Signaling in Cancer-Associated Fibroblasts and Tumor Immunity
The transcription factor SOX9 is a critical regulator in development, but its dysregulation in the tumor microenvironment (TME) is increasingly recognized as a pivotal driver of cancer progression.
Targeting SOX9 with CRISPR-Cas9: A Guide for Immune Cell Engineering in Cancer and Disease
This article provides a comprehensive resource for researchers and drug development professionals on the application of CRISPR-Cas9 technology for modulating SOX9 in immune cell models.
SOX9 in Autoimmunity and Inflammation: A Janus-Faced Regulator in Disease Pathogenesis and Therapeutic Development
This article comprehensively examines the dual role of the transcription factor SOX9 in autoimmune and inflammatory disorders.
SOX9 in Cancer Immune Escape: Mechanisms, Checkpoint Pathways, and Therapeutic Targeting
This article synthesizes current research on the transcription factor SOX9, detailing its complex, dual role as a master regulator of cancer immune evasion and a key player in maintaining tissue...
SOX9: A Janus-Faced Regulator in Inflammation, Tissue Repair, and Therapeutic Innovation
This review synthesizes current knowledge on the transcription factor SOX9, highlighting its complex, dual role in inflammatory diseases and tissue repair.
SOX9 in Cancer Immunity: Mechanisms, Biomarker Potential, and Therapeutic Targeting of the Tumor Microenvironment
The transcription factor SOX9 is a pivotal, yet dualistic, regulator of the tumor immune microenvironment.
SOX9 in T Cell Biology: Dual Roles in Differentiation, Function, and Therapeutic Potential
This article synthesizes current knowledge on the transcription factor SOX9 as a pivotal regulator in T cell differentiation and function.