Research Articles
SOX9: A Janus-Faced Regulator of Innate and Adaptive Immunity in Disease and Therapy
This review synthesizes current knowledge on the transcription factor SOX9, a pivotal but dualistic regulator of both innate and adaptive immune mechanisms.
SOX9: The Prototypical Janus-Faced Regulator in Immunity and Disease
The transcription factor SOX9 is a critical yet paradoxical regulator of the immune system, functioning as a double-edged sword in health and disease.
SOX9 in the Tumor Immune Microenvironment: A Double-Edged Sword in Cancer Progression and Therapy
This article synthesizes current knowledge on the transcription factor SOX9, a pivotal yet dualistic regulator within the tumor immune microenvironment (TIME).
Cross-Validation of Lipidomic Biomarkers Across Diverse Populations: From Discovery to Clinical Application
This article provides a comprehensive framework for the cross-validation of lipidomic findings across different populations, a critical step for translating lipid biomarkers into clinical practice.
Lipid Metabolite Signatures in Diabetic Complications: A Comparative Review of Pathophysiology, Biomarkers, and Clinical Applications
Diabetic microvascular complications, including kidney disease, retinopathy, and neuropathy, are major drivers of morbidity, yet their progression varies significantly among individuals.
Targeted vs. Untargeted Lipidomics in Diabetes Research: Strategies for Biomarker Discovery and Clinical Translation
This article provides a comprehensive analysis of targeted and untargeted lipidomics and their transformative role in diabetes research.
UHPLC-MS/MS in Lipidomics: A Comparative Analysis of Platforms for Biomedical Research
This article provides a comprehensive comparison of UHPLC-MS/MS against other established lipidomics platforms for researchers and drug development professionals.
Multi-Center Validation of Lipidomic Biomarkers: From Discovery to Clinical Application
The integration of lipidomics with machine learning is revolutionizing non-invasive diagnostic biomarker discovery for a wide range of diseases, including cancer, rheumatoid arthritis, and congenital conditions.
Distinct Lipidomic Signatures in Diabetes with Hyperuricemia: Biomarker Discovery, Pathophysiological Insights, and Clinical Implications
This article provides a comprehensive analysis of the distinct plasma lipidomic profiles that differentiate patients with diabetes mellitus (DM) from those with diabetes and comorbid hyperuricemia (DH).
Validating Lipid Biomarkers for Diabetes: From Discovery to Clinical Application in Independent Cohorts
This article provides a comprehensive roadmap for the validation of lipid biomarkers in diabetes research, addressing the critical gap between initial discovery and clinical application.