Research Articles
Beyond Situs Inversus: Advanced Strategies for Detecting Primary Ciliary Dyskinesia in Patients Without Laterality Defects
Primary Ciliary Dyskinesia (PCD) remains significantly underdiagnosed in patients who do not present with the classic hallmark of organ laterality defects.
Beyond PICADAR: Addressing Diagnostic Gaps and False Negatives in Primary Ciliary Dyskinesia
This article examines the significant limitations of the PICADAR predictive tool in identifying Primary Ciliary Dyskinesia (PCD), particularly its concerning false-negative rates in patients without classic laterality defects or hallmark...
Navigating Normal Ultrastructure: A Comprehensive Guide to PCD Diagnosis and Genetic Resolution
Diagnosing Primary Ciliary Dyskinesia (PCD) in patients with normal ciliary ultrastructure presents a significant challenge, requiring a shift from traditional diagnostic paradigms.
Beyond the Baseline: Strategies to Enhance PICADAR Sensitivity for Improved PCD Diagnosis
The Primary Ciliary Dyskinesia Rule (PICADAR) is a recommended predictive tool for estimating the likelihood of Primary Ciliary Dyskinesia (PCD), but recent evidence reveals critical limitations in its sensitivity, particularly...
PICADAR in Primary Care: A Critical Evaluation for Researchers and Drug Development Professionals
This article provides a comprehensive analysis of the PICADAR (PrImary CiliARy DyskinesiA Rule) predictive tool for primary ciliary dyskinesia (PCD), tailored for researchers, scientists, and drug development professionals.
PICADAR Score Sensitivity: A Critical Evaluation for PCD Diagnosis in Clinical Research and Trial Design
This article provides a comprehensive analysis of the PICADAR score's sensitivity as a predictive tool for Primary Ciliary Dyskinesia (PCD), a rare genetic disorder.
Re-evaluating PICADAR: Performance Limitations in Genetically Confirmed Primary Ciliary Dyskinesia Diagnosis
This article critically examines the diagnostic performance of the PICADAR (PrImary CiliARy DyskinesiA Rule) prediction tool in cohorts with genetically confirmed Primary Ciliary Dyskinesia (PCD).
PICADAR in PCD Diagnosis: A Critical Appraisal for Researchers and Drug Developers
This article provides a comprehensive analysis of the PICADAR (PrImary CiliARy DyskinesiA Rule) tool within the modern Primary Ciliary Dyskinesia (PCD) diagnostic workflow.
Long-Term Safety of CRISPR Systems: A Comprehensive 2025 Review of Genomic Risks, Clinical Progress, and Safety Mitigation
This article provides a critical analysis of the long-term safety profiles of major CRISPR-Cas systems, including nucleases, base editors, and prime editors, for a professional audience of researchers and drug...
Viral vs. Non-Viral Vectors for CRISPR Delivery: A 2025 Analysis of Efficiency, Safety, and Clinical Translation
This article provides a comprehensive analysis of viral and non-viral delivery vectors for CRISPR-Cas9 therapeutics, tailored for researchers and drug development professionals.