Research Articles
In Vivo vs Ex Vivo CRISPR-Cas9 Therapy: 2025 Clinical Approaches, Challenges, and Future Directions
This article provides a comprehensive analysis of in vivo and ex vivo CRISPR-Cas9 therapeutic approaches for researchers and drug development professionals.
Assessing Fusion Gene Detection Sensitivity of the AmpliSeq Childhood Cancer Panel: A Comprehensive Guide for Research and Diagnostic Applications
This article provides a comprehensive evaluation of the AmpliSeq™ for Illumina® Childhood Cancer Panel, a targeted NGS solution for fusion gene detection in pediatric and young adult cancers.
Amplicon Contamination: Sources, Prevention, and Decontamination Strategies for Research Laboratories
Amplicon contamination is a pervasive challenge in molecular biology, leading to false-positive results that can compromise research integrity and diagnostic accuracy.
SOX9 as a Clinical Biomarker: Validating Its Role in Therapy Resistance and Patient Stratification Across Cancers
This article synthesizes current evidence for validating the transcription factor SOX9 as a clinical biomarker in oncology.
Mastering SOX9 Detection in Immune Cells: A Comprehensive Guide for Biomarker Discovery and Therapeutic Targeting
This article provides a definitive resource for researchers and drug development professionals on the critical techniques and considerations for detecting the transcription factor SOX9 within diverse immune cell subpopulations.
Mastering SOX9 ChIP-seq: A Comprehensive Protocol for Mapping Immune Cell Transcription Factor Networks
This article provides a comprehensive guide for implementing Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) to study the transcription factor SOX9 in immune cells.
Comparative Analysis of m6A-Related lncRNA Signatures: Prognostic and Therapeutic Implications Across Major Cancer Types
This review synthesizes the rapidly evolving field of N6-methyladenosine (m6A)-modified long non-coding RNAs (lncRNAs) and their utility as prognostic signatures across diverse cancers.
m6A-Related lncRNA Signatures: Outperforming Traditional Staging in Cancer Prognosis and Treatment
This article explores the transformative potential of m6A-related long non-coding RNA (lncRNA) signatures as a novel class of biomarkers in oncology.
Navigating Missing Data in m6A-lncRNA Multivariate Analysis: A Comprehensive Guide for Clinical and Translational Researchers
This article provides a comprehensive guide for researchers and drug development professionals on addressing the critical challenge of missing data in multivariate analyses of m6A-related long non-coding RNAs (lncRNAs).
Navigating Batch Effects in Multi-Cohort m6A-lncRNA Studies: A Comprehensive Guide from Discovery to Clinical Validation
The integration of multi-cohort data is paramount for validating robust m6A-related lncRNA signatures in cancer research, yet it is severely compromised by pervasive batch effects.