Research Articles
Lipid Metabolism and Small Extracellular Vesicle Biogenesis in Cancer: Mechanisms, Biomarkers, and Therapeutic Targeting
This article synthesizes current research on the critical interface between lipid metabolism and small extracellular vesicle (sEV) biogenesis in cancer.
Non-Coding RNAs in Hepatocellular Carcinoma: Molecular Classification, Clinical Applications, and Future Therapeutics
Hepatocellular carcinoma (HCC) is a global health challenge with high mortality, often due to late-stage diagnosis and limited treatment options.
Biomolecular Condensates and Protein Aggregates in Human Disease: From Basic Mechanisms to Therapeutic Targeting
This article provides a comprehensive exploration of biomolecular condensates and protein aggregates, highlighting their dual roles in physiological processes and disease pathogenesis.
Protein Side-Chain Rotamers: From Statistical Foundations to AI-Driven Prediction in Drug Discovery
This article provides a comprehensive overview of the statistical conformations of protein side-chain rotamers, a critical field for understanding protein structure and function.
UHPLC-MS/MS Lipidomics in Metabolic Disease: Unraveling Lipid Pathways in Diabetes and Hyperuricemia
Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) has emerged as a powerful tool for uncovering lipidomic signatures in complex metabolic disorders.
Molecular Underpinnings of Genetic and Rare Diseases: From Genomic Discovery to Precision Therapies
This article provides a comprehensive analysis of the molecular mechanisms, diagnostic technologies, and therapeutic innovations shaping the understanding and treatment of genetic and rare diseases.
Decoding Hypoxia Tolerance: From Molecular Sensors to Therapeutic Innovations
This review synthesizes current research on the physiological and molecular mechanisms of hypoxia tolerance, a critical area for understanding disease pathology and developing therapeutic interventions.
SOX9: The Janus-Faced Regulator of Immunity and Its Emerging Promise as a Therapeutic Target
This review synthesizes current research on the transcription factor SOX9, highlighting its complex and context-dependent dual roles in immunology. For researchers and drug development professionals, we explore SOX9's foundational biology, from its structure and regulation to its critical functions in immune cell development, tumor immunology, and inflammatory tissue repair. The article details methodological approaches for studying SOX9, analyzes challenges in therapeutic targeting, including its paradoxical roles and drug resistance, and provides a comparative validation of its potential as a biomarker and therapeutic target across cancer and inflammatory diseases. We conclude by evaluating the future trajectory of SOX9-targeted therapies in clinical translation.
The Genetic Time Capsules in Lizards: Rewriting Evolutionary History
Discover how mitochondrial genomes in acrodont lizards reveal surprising evolutionary history through genetic reshuffling and biogeographic analysis.
Molecular Automata: How Protein Complexes Compute in Living Cells
Discover how protein complexes function as molecular automata, performing computational tasks that guide cellular behavior through non-equilibrium dynamics.