Research Articles
SOX9 Inhibition: A Novel Paradigm to Overcome Immunotherapy Resistance in Cancer
This article synthesizes current research on the transcription factor SOX9 as a master regulator of tumor immune evasion and therapy resistance.
Advanced Strategies for Improving Lipid Identification Accuracy in UHPLC-MS/MS Analysis
This article provides a comprehensive guide for researchers and drug development professionals seeking to enhance lipid identification accuracy using UHPLC-MS/MS technologies.
MTBE Lipid Extraction from Plasma: A Comprehensive Guide for Robust and Multi-Omic Lipidomics
This article provides a complete resource for researchers and scientists employing methyl-tert-butyl ether (MTBE) for lipid extraction from plasma.
Glycerophospholipid Metabolic Reprogramming in Diabetes and Hyperuricemia: Mechanisms, Biomarkers, and Therapeutic Avenues
This article synthesizes current evidence on the critical role of glycerophospholipid metabolism in the pathophysiology of diabetes mellitus (DM) and hyperuricemia (HUA).
SOX9: The Janus-Faced Regulator of Immunity and Its Emerging Promise as a Therapeutic Target
This review synthesizes current research on the transcription factor SOX9, highlighting its complex and context-dependent dual roles in immunology.
Beyond the Blur: A Modern Toolkit for Enhancing X-Ray Diffraction Resolution
This article provides a comprehensive guide for researchers and scientists facing the common challenge of poor diffraction resolution.
Strategies for Overcoming Flexible Domains in Protein Crystallization: From Foundational Concepts to Advanced Applications
This article provides a comprehensive guide for researchers and drug development professionals tackling the pervasive challenge of molecular flexibility in crystallization.
Optimizing Protein Purity for Crystallography: A Comprehensive Guide from Construct to Crystal
This article provides a detailed roadmap for researchers and drug development professionals to optimize protein purity for successful crystallization and high-resolution structure determination.
Troubleshooting Protein Crystallization Failures: A Strategic Guide for Researchers
This article provides a comprehensive, step-by-step framework for researchers and drug development professionals to diagnose and overcome common protein crystallization failures.
Advanced Cryoprotection Methods for Protein Crystallography: A Comprehensive Guide for Structural Biologists
This article provides a comprehensive overview of modern cryoprotection strategies essential for successful macromolecular crystallography.