Research Articles
Optimizing Precipitant Concentration for High-Resolution Protein Crystallization: Strategies for Researchers
This article provides a comprehensive guide for researchers and drug development professionals on optimizing precipitant concentration to grow high-quality protein crystals suitable for X-ray diffraction.
Serial Femtosecond Crystallography with XFELs: A Comprehensive Guide to Methods, Applications, and Future Directions in Structural Biology
Serial Femtosecond Crystallography (SFX) using X-ray Free-Electron Lasers (XFELs) represents a paradigm shift in structural biology.
Advanced Seeding Techniques for Optimizing Crystal Size Distribution in Pharmaceutical Development
This article provides a comprehensive guide to seeding techniques for controlling crystal size distribution (CSD) in pharmaceutical crystallization.
High-Throughput Protein Crystallization Screens: A Modern Guide for Accelerated Drug Discovery and Structural Biology
This article provides a comprehensive guide to high-throughput protein crystallization, a critical technology for determining 3D protein structures in structural biology and rational drug design.
Advanced Data Collection Strategies for Protein Crystallography: A 2025 Guide from Foundations to AI Integration
This article provides a comprehensive guide to modern data collection strategies in protein crystallography, tailored for researchers and drug development professionals.
PROLSQ in Structural Biology: Foundations, Evolution, and Modern Applications in Drug Discovery
This article provides a comprehensive examination of PROLSQ, a foundational method for protein structure refinement using stereochemical restraint libraries.
Molecular Replacement Phasing: From AlphaFold Revolution to Advanced Structure Solution
This comprehensive article explores molecular replacement (MR) phasing, a cornerstone technique in macromolecular crystallography.
Hanging Drop Vapor Diffusion: A Foundational Guide to Protein Crystallization for Structural Biology
This article provides a comprehensive resource on the hanging drop vapor diffusion method, a cornerstone technique for protein crystallization in structural biology and drug design.
Protein Crystallization Optimization: A Comprehensive Guide from Fundamentals to Advanced Applications
This article provides a comprehensive guide to protein crystallization optimization, essential for structural biology and drug development.
Protein Structure Analysis and Validation in 2025: A Comprehensive Guide for Biomedical Researchers
This article provides a comprehensive overview of the current landscape of protein structure analysis and validation, tailored for researchers, scientists, and drug development professionals.